| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-235 | |
| Phytochemical name or plant extracts | Salidroside | |
| PMID | 25814002 | |
| Literature evidence | In conclusion, these findings suggest that salidroside may be a promising candidate target for the prevention and treatment of human breast cancer. | |
| IUPAC name | (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Glycoside | |
| Source of phytochemicals or plant Extracts | Rhodiola rosea | |
| Geographical availability | Alaska, Albania, Altay, Amur, Austria, Bulgaria, Buryatiya, China North-Central, Chita, Czechoslovakia, East European Russia, Finland, France, Føroyar, Germany, Great Britain, Greenland, Iceland, Inner Mongolia, Ireland, Irkutsk, Italy, Japan, Kamchatka, Kazakhstan, Khabarovsk, Korea, Krasnoyarsk, Kuril Is., Labrador, Magadan, Maine, Manchuria, Mongolia, New Brunswick, New York, Newfoundland, North Carolina, North European Russi, Norway, Nova Scotia, Pennsylvania, Poland, Primorye, Québec, Romania, Sakhalin, Spain, Svalbard, Sweden, Switzerland, Tuva, Ukraine, Vermont, West Siberia, Xinjiang, Yakutskiya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | MAPK pathway | |
| IC50 | 19.48 μM against MCF-7 | |
| Potency | In conclusion, these findings suggest that salidroside may be a promising candidate target for the prevention and treatment of human breast cancer. | |
| Cell line/ mice model | MCF-7, Female BALB/c nude mice | |
| Additional information | We also further disclosed that salidroside treatment significantly inhibited the intracellular reactive oxygen species (ROS) formation and MAPK pathway activation, which may contribute to the inhibition of tumor growth of breast cancer and reduction of oxidative stress. | |
| PubChem ID | 159278 | |
| Additional PMIDs | 20541529 25814002 31918283 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:315148-2 | |
| Safety | NA |