| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1731 | |
| Phytochemical name or plant extracts | Saikosaponin-d (SSd) | |
| PMID | 19819234 | |
| Literature evidence | Co-incubation of MCF-7 cells with 1 microM of ER antagonist ICI-182780 abolished the inductive effects of SSd on estrogen response element (ERE)-luciferase activity, suggesting that the estrogenic effects of SSd were mediated through the estrogen receptors. | |
| IUPAC name | (2R,3S,4S,5R,6S)-2-[(2R,3R,5R,6R)-3,5-dihydroxy-2-[[(1S,2R,4S,5R,8R,9R,10S,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-10-yl]oxy]-6-methyloxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Saponin | |
| Source of phytochemicals or plant Extracts | Bupleurum falcatum | |
| Geographical availability | Albania, Austria, Belgium, Bulgaria, Central European Rus, Corse, Czechoslovakia, East European Russia, France, Germany, Great Britain, Hungary, Italy, Krym, North Caucasus, Poland, Romania, South European Russi, Switzerland, Transcaucasus, Ukraine, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | 1) The present study revealed that SSD induced apoptosis through the activation of the p38 mitogen‑activated protein kinase (MAPK) signaling pathway in human breast cancer MDA-MB-231 cells. 2) The results showed that SSd could activate ERE-luciferase activity via the ERalpha-mediated pathway in a dose-dependent manner (10 nM to 10 microM), whereas, the activation of ERbeta-mediated ERE-luciferase activity by SSd only occurred at a high concentration (10 microM). | |
| IC50 | NA | |
| Potency | In conclusion, the results of the present study indicated that SSd may represent a potent reversal agent for P-gp-mediated MDR in breast cancer therapy. | |
| Cell line/ mice model | MCF-7, HeLa, MDA-MB-231 | |
| Additional information | Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells. | |
| PubChem ID | 129637783 | |
| Additional PMIDs | 32468000 19819234 28554760 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:839147-1 | |
| Safety | NA |