| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-892 | |
| Phytochemical name or plant extracts | Saikosaponin A | |
| PMID | 34776948 | |
| Literature evidence | However, whether SSA can inhibit angiogenesis, a key step in solid tumor progression, remains unknown. | |
| IUPAC name | (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-3,5-dihydroxy-2-[[(1S,2S,4S,5R,8R,9R,10S,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-10-yl]oxy]-6-methyloxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid Saponin | |
| Source of phytochemicals or plant Extracts | Bupleurum chinense | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Inner Mongolia, Korea, Manchuria, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Colorectal cancer, Liver cancer, Stomach cancer | |
| Target gene or protein | VEGFR2, PLCγ1, FAK, Src, AKT | |
| Gene or Protein evidence | Western blot assay indicated the antiangiogenic mechanism of SSA in the suppression of the protein phosphorylation of VEGFR2 and the downstream protein kinase including PLCγ1, FAK, Src, and Akt. | |
| Target pathways | VEGFR2-mediated signaling pathway | |
| IC50 | NA | |
| Potency | Saikosaponin A showed the most potent cytotoxicity against human cancer cells (gastric cancer, AGS cells, breast cancer, MCF-7 cells, and hepatoma, HepG2 cells) after 24 h. | |
| Cell line/ mice model | 4T1, MCF-7, HCT-15, AGS, HepG2 | |
| Additional information | Saikosaponin A Inhibits Breast Cancer by Regulating Th1/Th2 Balance. | |
| PubChem ID | 167928 | |
| Additional PMIDs | 31214035 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:839099-1 | |
| Safety | NA |