| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1990 | |
| Phytochemical name or plant extracts | SANT, a novel Chinese herbal monomer combination | |
| PMID | 33011366 | |
| Literature evidence | It also provides novel strategies for using natural compounds to achieve optimized effect. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Combination of AS-IV, α-solanine, NEF, TMP, named ‘SANT’ | |
| Source of phytochemicals or plant Extracts | Astragaloside IV - Astragalus membranaceus, α-solanine - Solanum nigruminn, neferine - otus plumule, and 2,3,5,6-tetramethylpyrazine -igusticum | |
| Geographical availability | Astragalus membranaceus - Altay, Amur, Buryatiya, China North-Central, China South-Central, Chita, Inner Mongolia, Irkutsk, Kazakhstan, Khabarovsk, Krasnoyarsk, Manchuria, Mongolia, Primorye, Qinghai, Sakhalin, Tibet, Tuva, West Siberia, Xinjiang, Yakutskiya Solanum nigrum - Afghanistan, Albania, Algeria, Altay, Amur, Andaman Is., Assam, Austria, Azores, Baleares, Baltic States, Bangladesh, Belarus, Belgium, Bulgaria, Canary Is., Cape Verde, Central European Rus, Chad, China North-Central, China South-Central, China Southeast, Chita, Corse, Cyprus, Czechoslovakia, Denmark, Djibouti, East Aegean Is., East European Russia, East Himalaya, Egypt, Eritrea, Ethiopia, Finland, France, Germany, Great Britain, Greece, Gulf States, Hungary, India, Inner Mongolia, Iran, Iraq, Ireland, Irkutsk, Italy, Japan, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Kuril Is., Kuwait, Laos, Lebanon-Syria, Libya, Madeira, Manchuria, Morocco, Myanmar, Nepal, Netherlands, Nicobar Is., North Caucasus, North European Russi, Northwest European R, Norway, Oman, Pakistan, Palestine, Poland, Portugal, Primorye, Romania, Sakhalin, Sardegna, Saudi Arabia, Selvagens, Sicilia, Sinai, South China Sea, South European Russi, Spain, Sudan, Sweden, Switzerland, Tadzhikistan, Taiwan, Thailand, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, Vietnam, West Himalaya, West Siberia, Western Sahara, Yemen, Yugoslavia Lotus plumule - Amur, Assam, Bangladesh, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, India, Iran, Japan, Jawa, Khabarovsk, Korea, Laos, Lesser Sunda Is., Malaya, Manchuria, Myanmar, Nepal, New Guinea, North Caucasus, Northern Territory, Pakistan, Philippines, Primorye, Queensland, South European Russi, Sri Lanka, Thailand, Transcaucasus, Ukraine, Vietnam, West Himalaya, Western Australia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ATG16L1, ATG9B, ATG4D, HB-EGF, thrombospondin-2, amphiregulin, leptin, IGFBP-9, EGF, coagulation factor III, and MMP9, serpin E1, platelet factor 4 | |
| Gene or Protein evidence | SANT also suppressed tumor growth and angiogenesis in-vivo. Human autophagy PCR array results indicated that SANT increased the ATG16L1, ATG9B, ATG4D gene expressions while decreased TMEM74 and TNF gene expressions.Angiogenesis proteome profiler results showed SANT reduced protein level of HB-EGF, thrombospondin-2, amphiregulin, leptin, IGFBP-9, EGF, coagulation factor III, and MMP-9 (pro and active form) in tumor, raised the protein expression of serpin E1 and platelet factor 4. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | SANT, a novel Chinese herbal monomer combination, decreasing tumor growth and angiogenesis via modulating autophagy in heparanase overexpressed triple-negative breast cancer | |
| Cell line/ mice model | MDA-MB-231 hpa (231-Hpa) and MDA-MB-231 mock (231-Mock), BALB/c nude mice | |
| Additional information | Heparanase plays a vital role in tumor metastasis and angiogenesis. Our data demonstrated that the herbal drugs combination SANT exerted a markedly inhibition effect on HPSE overexpressed TNBC models invivo and in-vitro. SANT also promoted autophagy flux and suppressed angiogenesis in tumors via modulating related gene and protein expressions. These findings indicated that herbal compounds SANT may be a promising candidate in adjunctive cancer treatments. It also provides novel strategies to expand the application of natural compounds. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |