| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-713 | |
| Phytochemical name or plant extracts | Rumex vesicarius extract | |
| PMID | 32210679 | |
| Literature evidence | As the phytochemicals and botanical crude extracts have proven their efficacy as natural antiangiogenic agents with minimum toxicities, there is need to explore varieties of medicinal plants for novel antiangiogenic compounds. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanol, Chloroform, ethyl acetate and n-hexane extract | |
| Source of phytochemicals or plant Extracts | Rumex vesicarius | |
| Geographical availability | Afghanistan, Algeria, Assam, Bangladesh, Canary Is., Cape Verde, Chad, Djibouti, Egypt, Eritrea, Gulf States, India, Iran, Iraq, Kuwait, Lebanon-Syria, Libya, Mauritania, Morocco, Myanmar, Niger, Oman, Pakistan, Palestine, Saudi Arabia, Sinai, Somalia, Sudan, Tunisia, West Himalaya, Western Sahara, Yemen | |
| Plant parts | Root, Stem, Leaves and Flowers | |
| Other cancers | Breast cancer, Colon carcinoma, Hepatocellular carcinoma | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | Chloroform extract of stem - 33.45 ± 0.24 µM against MCF-7 Ethyl acetate extract of stem - 64.26 ± 0.33 µM against MCF-7 The IC50 values of the crude extracts prepared from the roots, and leaves were above than 500 µM. | |
| Potency | R. vesicarius can further be tested in clinical trials in order to explore its therapeutic potential as an effective and safe natural anticancer product. | |
| Cell line/ mice model | MCF-7, HepG2, Lovo, Caco-2 | |
| Additional information | Moreover, the crude extract prepared from other plants parts such as roots, leaves and flowers of R. vesicarius were completely in active in term of antiangiogenic activity in transgenic zebrafish embryos. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:697616-1 | |
| Safety | NA |