| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-711 | |
| Phytochemical name or plant extracts | Rumex dentatus extract | |
| PMID | 32186147 | |
| Literature evidence | Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic Extract | |
| Source of phytochemicals or plant Extracts | Rumex dentatus | |
| Geographical availability | Afghanistan, Albania, Assam, Bangladesh, Bulgaria, China North-Central, China South-Central, China Southeast, Cyprus, East Himalaya, Egypt, Greece, Gulf States, India, Inner Mongolia, Iran, Iraq, Japan, Kazakhstan, Kirgizstan, Korea, Kuril Is., Laos, Lebanon-Syria, Libya, Myanmar, Nansei-shoto, Nepal, North Caucasus, Oman, Pakistan, Palestine, Qinghai, Romania, Saudi Arabia, Sinai, South European Russi, Tadzhikistan, Taiwan, Transcaucasus, Tunisia, Turkey, Turkmenistan, Ukraine, Uzbekistan, Vietnam, West Himalaya, Xinjiang, Yemen | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Larynx carcinoma, Prostate carcinoma | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NF-κB Pathway | |
| IC50 | Among all the studied extracts, ethanolic extract showed highest cytotoxicity against MCF-7 cell line then Hep-2 and DU-145 cell lines by MTT assay with lowest IC50 of 47.3 μg/mL. | |
| Potency | Rumex dentatus Inhibits Cell Proliferation, Arrests Cell Cycle, and Induces Apoptosis in MDA-MB-231 Cells through Suppression of the NF-κB Pathway | |
| Cell line/ mice model | MCF-7, Hep-2, DU-145 | |
| Additional information | These results suggest that R. dentatus could be a potent alternative candidate for treatment of microbial infections and for breast cancer treatment. | |
| PubChem ID | NA | |
| Additional PMIDs | 29075192 32186147 22252500 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:697039-1 | |
| Safety | NA |