| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-776 | |
| Phytochemical name or plant extracts | Rotundic acid | |
| PMID | 25156290 | |
| Literature evidence | Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity. | |
| IUPAC name | (1R,2R,4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-1,10-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Mitragyna diversifolia | |
| Geographical availability | Bangladesh, Cambodia, China South-Central, Jawa, Laos, Malaya, Myanmar, Philippines, Thailand, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Rotundic acid induces Cas3-MCF-7 cell apoptosis through the p53 pathway | |
| IC50 | > 50 μmol/L against MCF-7 | |
| Potency | RA has the potential for development as a novel drug combined with reconstitution of caspase-3 gene therapy for the treatment of human breast cancer with caspase-3 deficiency. | |
| Cell line/ mice model | MCF-7, HT-29 | |
| Additional information | RA protects against HFD-induced NASH via downregulating the expression of SREBP-1c/SCD1 signaling pathway and improving gut microbiota. | |
| PubChem ID | 12315075 | |
| Additional PMIDs | 30655810 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:756293-1 | |
| Safety | NA |