| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1447 | |
| Phytochemical name or plant extracts | Rosmarinus officinalis extract | |
| PMID | 32188380 | |
| Literature evidence | DISCUSSION: At a low concentration of 10 μg/mL, C. hybridus calli and seedling extracts showed the most significant anti-proliferative effects after 24 and 48 h of exposure (p < 0.01), controls (doxorubicin) also showed significant inhibition, but lesser than that observed with C. hybridus (p < 0.05). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract, Methanolic crude extract | |
| Source of phytochemicals or plant Extracts | Rosmarinus officinalis | |
| Geographical availability | Albania, Algeria, Baleares, Corse, Cyprus, East Aegean Is., Egypt, France, Greece, Italy, Libya, Morocco, Portugal, Sardegna, Sicilia, Spain, Tunisia, Turkey, Yugoslavia | |
| Plant parts | Leaves and seedlings | |
| Other cancers | Breast cancer, Colorectal cancer, Cervical cancer, Leukemia, Lung cancer, Prostate cancer | |
| Target gene or protein | ER-α, HER2 | |
| Gene or Protein evidence | We found that SFRE exerts antitumor activity against breast cancer cells from different tumor subtypes and the downregulation of ER-α and HER2 receptors by SFRE might be involved in its antitumor effect against estrogen-dependent (ER+) and HER2 overexpressing (HER2+) breast cancer subtypes. | |
| Target pathways | ER-α and HER2 signaling pathways | |
| IC50 | Leaves ethanolic extract - 4.8 × 10-1 mg/mL against MDA-MB-231 | |
| Potency | Methanolic extracts of R. officinalis and C. hybridus are potentially valuable options for breast cancer treatment. | |
| Cell line/ mice model | MCF-7, LoVo, HeLa, RAW 264.7, FMM-1, NIH3T3, MDA-MB-231, 5637,Jurkat, K562, HL60, NCI-H82, DU-145, Hep-3B, PC-3, LNCaP | |
| Additional information | Shows anti-proliferative effects against MCF-7 cells Causes significant (47%) decrease in mamary tumour incidence, and Inhibits total in vivo binding of DMBA to mammary epithelial cell DNA by an average of 42% through inhibiton of the syn-dGuo adduct and anti-dGuo adduct Posesses both antioxidant activity and the capability to scavenge hydrogen peroxide Causes downregulation of ER-? and HER2 receptors (supercritical fluid rosemary extract (SFRE)) Significantly reduces IL-1beta (p<0.01) ,COX-2 (p<0.05) mRNA expression and NO production, and non-significantly reduces TNFalpha and iNOS mRNA expression (LPS-activated cells) | |
| PubChem ID | NA | |
| Additional PMIDs | 26408343 28093936 1933840 33418860 20942618 24615943 25141946 17487414 20449663 24031588 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:455509-1 | |
| Safety | NA |