| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-410 | |
| Phytochemical name or plant extracts | Rosemary extract | |
| PMID | 17487414 | |
| Literature evidence | The 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (Trolox) equivalent antioxidant capacity assay showed that RO has substantial antioxidant activity with RO at 1/10 and 1/5 dilutions having 8.1 and 12.6 microM Trolox equivalents, respectively. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Rosmarinus officinalis | |
| Geographical availability | Albania, Algeria, Baleares, Corse, Cyprus, East Aegean Is., Egypt, France, Greece, Italy, Libya, Morocco, Portugal, Sardegna, Sicilia, Spain, Tunisia, Turkey, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | TNF-α, IL-1β, iNOS, COX-2 | |
| Gene or Protein evidence | At 1/500 dilution, RO significantly reduced IL-1beta (p<0.01) and COX-2 (p<0.05) mRNA expression and non-significantly reduced TNFalpha and iNOS mRNA expression in the LPS-activated cells. | |
| Target pathways | Akt, and mTOR Signaling | |
| IC50 | 28.86 µg/mL against MDA-MB-231 | |
| Potency | The 50% inhibitory concentration (IC50) was estimated at 1/700, 1/400, 1/150 and 1/500 dilutions, for the HL60, K562, MCF7 and MDA-MB-468 cells, respectively. Non-cytotoxic concentrations of RO at 1/1000 dilution minimally induced HL60 cell differentiation into granulocyte lineage at 9.5+/-2.2% compared to 2.8+/-0.8% in the untreated control (p<0.001), and did not induce HL60 cell differentiation into monocyte/macrophage lineage. | |
| Cell line/ mice model | HL60, K562, MCF-7, MDA-MB-468, MDA-MB-231 | |
| Additional information | The 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid (Trolox) equivalent antioxidant capacity assay showed that RO has substantial antioxidant activity with RO at 1/10 and 1/5 dilutions having 8.1 and 12.6 microM Trolox equivalents, respectively. | |
| PubChem ID | NA | |
| Additional PMIDs | 32012648 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:457138-1 | |
| Safety | NA |