| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-0 | |
| Phytochemical name or plant extracts | Rocaglaol | |
| PMID | 16619491 | |
| Literature evidence | It exhibited in vitro cytotoxic activity against Lu1, LNCaP and MCF-7 cells with ED50 values of 13.8, 23.0 and 9.2 nM, respectively. | |
| IUPAC name | (1R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-1,8b-diol | |
| Phytochemicals’ class or type of plant extracts | Cyclopenta[b]benzofuran | |
| Source of phytochemicals or plant Extracts | Aglaia crassinervia | |
| Geographical availability | Borneo, Malaya, Myanmar, Nicobar Is., Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Prostate cancer, Colorectal cancer, Leukemia, Liver cancer, Lung cancer | |
| Target gene or protein | Bax, Bcl-xL, Caspase 9, Caspase 7, Cdc25c | |
| Gene or Protein evidence | Rocaglaol treatment induced Bax expression through 12 to 72 h of exposure, while Bcl-xl expression was slightly decreased through 48 h, and decreased more significantly by 72 h. Cleaved caspase-9 expression was detected at 72 h, and cleaved caspase-7 was increased through 48 to 72 h. In addition, protein phosphatase Cdc25C, which functions as a mitotic activator by dephosphorylation of Cdc2, decreased in a time-dependent manner after rocaglaol treatment. | |
| Target pathways | Mitochondrial pathway | |
| IC50 | 0.008 µM against MCF-7 | |
| Potency | Rocaglaol is a cytotoxic cyclopenta[b]benzofuran isolated from the bark of Aglaia crassinervia. It exhibited in vitro cytotoxic activity against Lu1, LNCaP and MCF-7 cells with ED50 values of 13.8, 23.0 and 9.2 nM, respectively. In summary, the data presented in this study indicate that rocaglaol is a potent cytotoxic agent that induces cell cycle arrest at the G2/M-phase and apoptosis through the mitochondrial pathway | |
| Cell line/ mice model | Lu1, LNCaP, HL-60, SMMC-7721, A-549, MCF-7, W480 | |
| Additional information | NA | |
| PubChem ID | 393602 | |
| Additional PMIDs | 25742723 | |
| Additional sources of information | https://powo.science.kew.org/taxon/577033-1 | |
| Safety | NA |