| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1516 | |
| Phytochemical name or plant extracts | Rocaglamide | |
| PMID | 25742723 | |
| Literature evidence | Among them, compounds 1 and 2 showed significant cytotoxicity against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values of 0.007-0.095 μM, while compounds 3-5 and 10 and 11 showed moderate to no cytotoxicity (IC50 0.43 to values >40 μM). | |
| IUPAC name | (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide | |
| Phytochemicals’ class or type of plant extracts | Organic heterotricyclic compound | |
| Source of phytochemicals or plant Extracts | Aglaia odorata | |
| Geographical availability | Cambodia, China Southeast, Hainan, Laos, Malaya, Thailand, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Colorectal cancer, Leukemia, Liver cancer, Lung cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 0.008 µM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7 and SW480 | |
| Additional information | NA | |
| PubChem ID | 331783 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:577227-1 | |
| Safety | NA |