| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-806 | |
| Phytochemical name or plant extracts | Robustaflavone A | |
| PMID | 33639365 | |
| Literature evidence | We aimed to evaluate the inhibitory effects of compounds 1-6 against human breast cancer MCF-7 cells. Among the six compounds, RF-A showed the strongest activity, decreasing cell viability with an IC50 value of 11.89 μΜ. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Selaginella trichoclada | |
| Geographical availability | China Southeast | |
| Plant parts | Whole herb | |
| Other cancers | Breast cancer | |
| Target gene or protein | VDAC2 channel, Nedd4 E3 ubiquitin ligase | |
| Gene or Protein evidence | Furthermore, RF-A strikingly induced MCF-7 nonapoptotic cell death through ferroptosis by enhancing the expression of VDAC2 channels and reducing the expression of Nedd4 E3 ubiquitin ligase, leading to lipid peroxidation and ROS production. | |
| Target pathways | Mitochondrial VDAC2 and Nedd4 pathways | |
| IC50 | 11.89 μΜ against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The results suggested that RF-A has potential as a novel breast cancer treatment through its regulation of the mitochondrial VDAC2 and Nedd4 pathways. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77186894-1 | |
| Safety | NA |