| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2164 | |
| Phytochemical name or plant extracts | Rigidusol | |
| PMID | 11140515 | |
| Literature evidence | Rigidusol exhibit moderate cytotoxic activity against human breast adenocarcinoma cell line MCF-7. | |
| IUPAC name | [(4aR,5S,6R,8aS)-5-(3-hydroxy-3-methylpent-4-enyl)-5,6,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]methyl acetate | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Haplopappus rigidus phil. | |
| Geographical availability | Argentina Northwest, Bolivia, Chile Central, Chile North | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | ED50 = 3.8 μg/mL against MCF-7 | |
| Additional information | Rigidusol 1 has moderate cytotoxicity to the human breast adenocarcinoma cell line MCF-7 showing ED50 3.8 mg/ ml compared with adriamicin with ED50 0.5 mg/ ml (Soule et al., 1973) while the compound was found to be inactive against human lung (A-549) and colon (HT- 29) tumor cell lines (ED50 >10 mg/ml). | |
| PubChem ID | 22297648 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:178082-1 | |
| Safety | NA |