| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-53 | |
| Phytochemical name or plant extracts | Rich Lady peach extract | |
| PMID | 19530711 | |
| Literature evidence | The concentration to inhibit 50% of cell proliferation (IC(50)) was approximately 42 mg/L for this cell line compared to an IC(50) of approximately 130 and approximately 515 mg/L for the noncancerous breast cell line MCF-10A and the estrogen-dependent breast cancer cell line MCF-7, respectively. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Crude phenolic extract | |
| Source of phytochemicals or plant Extracts | Prunus persica | |
| Geographical availability | China North-Central | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 42 mg/L against MDA-MB-435 515 mg/L against MCF-7 | |
| Potency | In general, RL extracts were more effective than BS extract in inhibiting the proliferation of the three cell lines, with the order of sensitivity being MDA-MB-435 > MCF-10A > MCF-7. | |
| Cell line/ mice model | MCF-7, MDA-MB-435, MCF-10A | |
| Additional information | In conclusion, peaches and plums contain a mixture of phenolic compounds that preferentially inhibit the growth of the estrogen-independent MDA-MB-435 breast cancer cells over either the estrogen-dependent MCF-7 breast cancer cells or the breast epithelial MCF-10A cells. However, we confirmed that phenolic acids present in F(1): chlorogenic and neo-chlorogenic acids have potential as chemopreventive dietary compounds because of the relatively high growth inhibition exerted on the estrogen-independent MDA-MB-435 breast cancer cell line and low toxicity exerted in the normal MCF-10A cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1212858-2 | |
| Safety | However, we confirmed that phenolic acids present in F(1): chlorogenic and neo-chlorogenic acids have potential as chemopreventive dietary compounds because of the relatively high growth inhibition exerted on the estrogen-independent MDA-MB-435 breast cancer cell line and low toxicity exerted in the normal MCF-10A cells. |