| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-30 | |
| Phytochemical name or plant extracts | Rhodoeosein | |
| PMID | 23768005 | |
| Literature evidence | CONCLUSION: This study is the first to characterize the novel flavan-3-ol compound, rhodoeosein, and its ability to induce estrogenic activity in human cell lines. | |
| IUPAC name | [5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3-(4-hydroxyphenyl)prop-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Flavan-3-ol | |
| Source of phytochemicals or plant Extracts | Fallopia convolvulus | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Amur, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Canary Is., Central European Rus, China North-Central, China South-Central, China Southeast, Chita, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, East Himalaya, Egypt, Finland, France, Føroyar, Germany, Greece, Hungary, India, Inner Mongolia, Iran, Iraq, Irkutsk, Italy, Kamchatka, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Kuril Is., Lebanon-Syria, Libya, Madeira, Magadan, Manchuria, Mongolia, Morocco, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Panamá, Poland, Portugal, Primorye, Qinghai, Romania, Sakhalin, Sardegna, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Uzbekistan, Vietnam, West Himalaya, West Siberia, Xinjiang, Yakutskiya, Yugoslavia | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERβ | |
| Gene or Protein evidence | Rhodoeosein and emodin may have potential therapeutic applications as natural products activating ERβ, and further characterization of rhodoeosein is necessary to evaluate its selectivity as a cell type-specific ER agonist. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Half-maximal induction (EC50) by rhodoeosein in ERα- and ERβ-transfected SKBR3 cells was 5.8 μM ± 1.5 μM and 18 μM ± 0.4 μM, respectively (significantly less potent than E2 which had EC50 values of 20 pM ± 1.5 nM and 270 pM ± 4.0 nM in ERα- and ERβ-transfected SKBR3 cells, respectively). | |
| Cell line/ mice model | SKBR-3 | |
| Additional information | This study is the first to characterize the novel flavan-3-ol compound, rhodoeosein, and its ability to induce estrogenic activity in human cell lines. Rhodoeosein and emodin may have potential therapeutic applications as natural products activating ERβ, and further characterization of rhodoeosein is necessary to evaluate its selectivity as a cell type-specific ER agonist. | |
| PubChem ID | 87057561 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:103354-2 | |
| Safety | NA |