| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1588 | |
| Phytochemical name or plant extracts | Rhodiola crenulata extract | |
| PMID | 18800886 | |
| Literature evidence | Rhodiola crenulata induces death and inhibits growth of breast cancer cell lines | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Phenolic phytochemical | |
| Source of phytochemicals or plant Extracts | Rhodiola crenulata | |
| Geographical availability | China South-Central, East Himalaya, Nepal, Qinghai, Tibet, West Himalaya | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | HIF1, MYCN | |
| Gene or Protein evidence | Upon Rhodiola crenulata extract treatment, HIF-1 transcriptional activity was increased. Through this work, we observed significant cytotoxic effects of Rhodiola crenulata extract treatment upon treatment on NB-1691 cells, a human neuroblastoma cell line with MYCN amplification. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Finally, an in vivo experiment showed that phenolic-enriched dietary R. crenulata is effective in preventing the initiation of tumors and slowing down the tumor growth in mice bearing tumor grafts, thereby further demonstrating its possible potential for treatment of breast cancer progression and metastasis. | |
| Cell line/ mice model | MDA-MB-231, mice bearing tumor graft, NB-1691 | |
| Additional information | In addition, the extracts induced autophagic-like vesicles in all cell lines, eventually leading to death of the tumor cell lines but not the immortal or normal human mammary epithelial cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 29871587 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:274793-1 | |
| Safety | NA |