| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1126 | |
| Phytochemical name or plant extracts | Regiolone | |
| PMID | 24467376 | |
| Literature evidence | MCF-7 growth inhibition was attributed to apoptosis, population of apoptotic cells increased from 1.12% in controls to 5.64 and 8.1% after 48-h treatment with compounds 6 and 7, indicating their potential at inducing early and late apoptosis. | |
| IUPAC name | (4R)-4,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Juglans regia | |
| Geographical availability | Afghanistan, Iran, Iraq, Lebanon-Syria, North Caucasus, Pakistan, Poland, Transcaucasus, Turkey, West Himalaya | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Oral cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Our results suggest that compounds 6 and 7 can induce apoptosis in MCF-7 cells through the caspase-3 independent pathway. | |
| IC50 | 21.30±3.5 μM against MCF-7 | |
| Potency | Results of our previously performed cytotoxic screening of different fractions obtained from J. regia leaves indicated that the chloroform fraction had the most potent activity on breast cancer cells. | |
| Cell line/ mice model | MCF-7, BHY | |
| Additional information | NA | |
| PubChem ID | 44576009 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:442427-1 | |
| Safety | Compounds 6 and 7 had potent cytotoxic effects on both MCF-7 and BHY cells (IC50 21-51 μm), yet were not toxic to normal cells. Compound 7 is Regiolone |