| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1949 | |
| Phytochemical name or plant extracts | Red-fleshedapple peel extract | |
| PMID | 34392532 | |
| Literature evidence | These results suggest that AFP and APP may be excellent sources of natural chemicals for treating triple-negative breast cancer MDA-MB-231 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Peel polyphenolic extract (APP) | |
| Source of phytochemicals or plant Extracts | Malus niedzwetzkyana | |
| Geographical availability | Afghanistan, Kazakhstan, Kirgizstan, Pakistan, Tadzhikistan, Uzbekistan, Xinjiang | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | pAKT, pBad, Bcl-2, cyt-c, Cle-Caspase 9, Cle-Caspase 3, Cle-PARP, p-p53, p21, PCNA, Cyclin D1 | |
| Gene or Protein evidence | Besides, the significant inhibition effects of APP and AFP were achieved through Akt pathway by inducing apoptosis (significantly upregulating reactive oxygen species [ROS] levels, and downregulating expression of pAkt, pBad, Bcl-2, promoting Cytochrome c release, activating Cle-Caspase 9, and inducing expressions of Cle-Caspase 3 and Cle-PARP), and inducing G0/G1 cell cycle arrest (increased expressions of p-p53 and p21 and decreased expressions of PCNA and Cyclin D1). | |
| Target pathways | Akt pathway | |
| IC50 | 662.97 µg/mL against MDA-MB-231 | |
| Potency | These findings suggest that AFP and APP have similar mechanisms of inhibiting human breast cancer MDA-MB231 cell proliferation, and that APP has stronger anticancer activity than AFP, which may be because APP contains more active substances than AFP or because it is more bioavailable. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | These results suggest that AFP and APP may be excellent sources of natural chemicals for treating triple-negative breast cancer MDA-MB-231 cells. PRACTICAL APPLICATION: The effects of antiproliferation of phenolic extracts from red-fleshed apple peels and flesh on human breast cancer MDA-MB-231 cells were evaluated. The data may clarify the functional parts of red-fleshed apple and provide some basis for scientific researchers and consumers to recognize and exploit red-fleshed apple. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:726346-1 | |
| Safety | NA |