| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1367 | |
| Phytochemical name or plant extracts | Red guava extracts | |
| PMID | 32410830 | |
| Literature evidence | We found that red guava extracts can, through caspase-3 activation and PARP cleavage signaling, induce apoptotic and necrotic death in TNBC cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Psidium guajava | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Bolivia, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Colombia, Ecuador, Paraguay, Peru, Venezuela | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, PARP | |
| Gene or Protein evidence | We found that red guava extracts can, through caspase-3 activation and PARP cleavage signaling, induce apoptotic and necrotic death in TNBC cells. | |
| Target pathways | caspase-3/PARP signaling pathway, PI3K/AKT pathway | |
| IC50 | At 24h, 72h: 29.85µg/mL, 5.964 µg/mL against MCF-7 respectively | |
| Potency | NA | |
| Cell line/ mice model | MCF-10A, MCF-7, NIH-3T3, MDA-MB-231 and MDA-MB-468 | |
| Additional information | Influenced over G2-M transition check-point of the cell cycle and increased apoptotic cells percentages compared to untreated cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 29433206 33641558 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:600841-1 | |
| Safety | NA |