| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1952 | |
| Phytochemical name or plant extracts | Raspberry oil emulsion: supercritical CO2 (ROSCO2) | |
| PMID | 34211628 | |
| Literature evidence | There are growing interests in the complex combinations of natural compounds that may advance the therapy of cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extracted by supercritical CO2 (ROSCO2) | |
| Source of phytochemicals or plant Extracts | Rubus idaeus | |
| Geographical availability | Alaska, Albania, Altay, Amur, Arizona, Austria, Baltic States, Belarus, Belgium, British Columbia, Bulgaria, Buryatiya, California, Central European Rus, China North-Central, China South-Central, Chita, Colorado, Connecticut, Corse, Czechoslovakia, Delaware, Denmark, District of Columbia, East European Russia, Finland, France, Germany, Great Britain, Greece, Hungary, Idaho, Illinois, Indiana, Inner Mongolia, Iowa, Ireland, Irkutsk, Italy, Japan, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Krym, Labrador, Magadan, Maine, Manchuria, Manitoba, Maryland, Massachusetts, Mexico Gulf, Mexico Northeast, Mexico Northwest, Michigan, Minnesota, Missouri, Mongolia, Montana, Nebraska, Netherlands, Nevada, New Brunswick, New Hampshire, New Jersey, New Mexico, New York, Newfoundland, North Carolina, North Caucasus, North Dakota, North European Russi, Northwest European R, Northwest Territorie, Norway, Nova Scotia, Nunavut, Ohio, Oklahoma, Ontario, Oregon, Pennsylvania, Poland, Primorye, Prince Edward I., Qinghai, Québec, Rhode I., Romania, Sakhalin, Saskatchewan, Sicilia, South Dakota, South European Russi, Spain, Sweden, Switzerland, Tennessee, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Utah, Vermont, Virginia, Washington, West Siberia, West Virginia, Wisconsin, Wyoming, Xinjiang, Yakutskiya, Yugoslavia, Yukon | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Lung cancer, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 69.4 % against MCF-7 and 48.3 % against MCF-7/DX | |
| Potency | ROSCO2 strongly induced free radical production and DNA strand damage in LoVo and MCF7 cells especially doxorubicin-resistant lines. | |
| Cell line/ mice model | MCF-7, MCF-7/DX, A549, LoVo, LoVo/DX | |
| Additional information | These data suggest that the way of oil manufacturing is important in terms of chemical characteristics, but what is also essential, may represent a cell suppression potential which may differ regarding the type of tumor. It is also important to conduct further investigations to determine the limitations for some other types of cancer. This study also showed that raspberry oil obtained by SCO2, due to its rich composition, may act in favor of chemoprevention of colon and breast cancers. We also observed that the metabolic activity of colon and breast cancer cell lines may be sensitive to the n-6/n-3 ratio. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:298089-2 | |
| Safety | Generally, both ROSCO2 and ROCOP could be a nontoxic support in therapy of selected human cancers. |