| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-138 | |
| Phytochemical name or plant extracts | Raddeanoside R13 | |
| PMID | 26810189 | |
| Literature evidence | These data highlight the important role of R13 in BC cell proliferation and progression and suggest that R13 may be a useful drug for BC therapy. | |
| IUPAC name | (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-4-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Saponin | |
| Source of phytochemicals or plant Extracts | Pulsatilla chinensis | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Inner Mongolia, Khabarovsk, Korea, Manchuria, Mongolia, Primorye, Qinghai | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, Cyclin A, Cyclin B1, PARP, Caspase 3 | |
| Gene or Protein evidence | Raddeanoside R13 (R13) inhibits BC cell proliferation via the activation of G1/S checkpoint transitions, concomitant with a marked decrease of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. R13 induces BC cell apoptosis accompanied by the increased levels of cleaved PARP and caspase-3. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Moreover, R13 suppresses BC tumor growth and metastasis in nude mice. These data highlight the important role of R13 in BC cell proliferation and progression and suggest that R13 may be a useful drug for BC therapy | |
| Cell line/ mice model | NA | |
| Additional information | NA | |
| PubChem ID | 11622076 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:20005205-1 | |
| Safety | NA |