| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-954 | |
| Phytochemical name or plant extracts | Rabdosia rubescens extract | |
| PMID | 15586232 | |
| Literature evidence | Our data showed that individual components of PC-SPES had varying suppressive effects on cellular proliferation, and that Rabdosia rubescens appeared to be the most potent agent in these assays. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Rabdosia rubescens | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT | |
| Gene or Protein evidence | We found that Oridonin, an extract from Rabdosia rubescens, reduced cell viability to the greatest extent. Oridonin binds to AKT1 and potentially functions as an ATP-competitive AKT inhibitor. | |
| Target pathways | MAPK (mitogen-activated protein kinase) and the Akt kinase pathways | |
| IC50 | NA | |
| Potency | We conclude that Rabdosia rubescens may potentially be used to treat or prevent breast cancer, and that the extract from this herbal source deserves further studies. | |
| Cell line/ mice model | MDA-MB-231 and HUVEC | |
| Additional information | In mouse experiments, the extract from Rabdosia rubescens suppressed breast cancer xenograft size and decreased the tumor vessel density. | |
| PubChem ID | NA | |
| Additional PMIDs | 29844859 17251686 15586232 23165347 23777360 29580806 15008459 19653147 15703811 16176802 23336515 28822194 28579904 30008931 22848306 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:915158-1 | |
| Safety | NA |