| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-805 | |
| Phytochemical name or plant extracts | Quinovic acid | |
| PMID | 32734538 | |
| Literature evidence | Our results indicate that QA mediates its anticancer effects, at least in part, by engaging DR5-depentent pathway to induce apoptosis. | |
| IUPAC name | (1S,2R,4aS,6aR,6aR,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6b,9,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a,6a-dicarboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Fagonia indica | |
| Geographical availability | Afghanistan, Algeria, Chad, Djibouti, Egypt, Eritrea, Ethiopia, Gulf States, India, Iran, Kenya, Kuwait, Libya, Mali, Mauritania, Morocco, Niger, Oman, Pakistan, Palestine, Saudi Arabia, Sinai, Somalia, Sudan, Western Sahara, Yemen | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 8, PARP | |
| Gene or Protein evidence | QA-induced cell death was associated with biochemical features of apoptosis such as activation of caspases 3 and 8 as well as PARP cleavage. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | QA also upregulated mRNA and protein levels of death receptor 5 (DR5). Further investigation revealed that QA did not alter DR5 gene promoter activity, but enhanced DR5 mRNA and protein stabilities. | |
| Cell line/ mice model | NA | |
| Additional information | Our results indicate that QA mediates its anticancer effects, at least in part, by engaging DR5-depentent pathway to induce apoptosis. | |
| PubChem ID | 120678 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77184914-1 | |
| Safety | NA |