| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-204 | |
| Phytochemical name or plant extracts | Quercus acutissima extract | |
| PMID | 34634366 | |
| Literature evidence | It was traditionally used by Chinese folk to inhibit tumor proliferation in cancerous treatment, but the specific mechanism remain to be elucidated. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Quercus acutissima | |
| Geographical availability | Assam, Cambodia, China North-Central, China South-Central, East Himalaya, Japan, Korea, Laos, Manchuria, Myanmar, Nepal, Thailand, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Beclin-1, Atg5, Bcl-W | |
| Gene or Protein evidence | Western blot indicated that QA root extract induced mitochondria-mediated apoptosis by up-regulating caspase 3 and down-regulating Bcl-W. Moreover, QA root extract up-regulated Beclin1 and Atg5, and activated LC3 in two human breast cancer cell lines. | |
| Target pathways | NA | |
| IC50 | 52.14 ± 2.1 µg/mL against MCF-7 | |
| Potency | QA root extract inhibited cell proliferation and migration in MCF-7 and SUM159 cells, and it also induced cell morphology changes and regulated mitochondria-mediated apoptotic cell death and autophagic cell death. | |
| Cell line/ mice model | SUM159, MCF-7, HeLa, Jurkat, HT-29 | |
| Additional information | QA root extract treatment induced the morphological and nuclear structural changes in breast cancer cells including rounded appearance and shrunken nucleus with several nuclear body fragments. | |
| PubChem ID | NA | |
| Additional PMIDs | 35092826 31717611 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:295743-1 | |
| Safety | NA |