| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-172 | |
| Phytochemical name or plant extracts | Quercetin-3-methyl ether | |
| PMID | 22086611 | |
| Literature evidence | Overall, these results suggested that quercetin-3-methyl ether might be a novel and promising therapeutic agent in lapatinib-sensitive or -resistant breast cancer patients. | |
| IUPAC name | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Wollastonia biflora | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Cambodia, Caroline Is., Chagos Archipelago, China South-Central, China Southeast, Christmas I., Cocos (Keeling) Is., Comoros, Cook Is., Fiji, Gilbert Is., Hainan, India, Jawa, Kazan-retto, KwaZulu-Natal, Laos, Malaya, Maldives, Marianas, Marshall Is., Mozambique, Mozambique Channel I, Myanmar, Nansei-shoto, New Caledonia, New South Wales, Nicobar Is., Niue, Norfolk Is., Northern Territory, Ogasawara-shoto, Philippines, Queensland, Samoa, South China Sea, Sri Lanka, Taiwan, Thailand, Tibet, Tonga, Tubuai Is., Tuvalu, Vanuatu, Vietnam, Wallis-Futuna Is. | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 7, PARP | |
| Gene or Protein evidence | Moreover, quercetin-3-methyl ether induced significant apoptosis, accompanied with increased levels of cleaved caspase 3, caspase 7, and poly(ADP-ribose) polymerase (PARP) in both cell lines. | |
| Target pathways | Chk1-Cdc25c-cyclin B1/Cdk1 pathway | |
| IC50 | NA | |
| Potency | Overall, these results suggested that quercetin-3-methyl ether might be a novel and promising therapeutic agent in lapatinib-sensitive or -resistant breast cancer patients. | |
| Cell line/ mice model | SKBR-3 | |
| Additional information | NA | |
| PubChem ID | 5280681 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:260687-1 | |
| Safety | NA |