| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-706 | |
| Phytochemical name or plant extracts | Quercetin-3-O-glucuronide | |
| PMID | 26922854 | |
| Literature evidence | Quercetin showed significant cytotoxic activity against HepG2 and MCF-7 cell lines with IC50 values of 4.88 and 0.87 μg/mL, respectively. | |
| IUPAC name | (2S,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Calligonum polygonoides | |
| Geographical availability | Gulf States, Iran, Iraq, Kuwait, Lebanon-Syria, Pakistan, Palestine, Saudi Arabia, Sinai, Transcaucasus, Turkey, Yemen | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 14.32 µg/ml against MCF-7 | |
| Potency | Quercetin, quercetin-3-O-glucuronide and taxifolin exhibited the highest cytotoxic effect against MCF-7 cells. | |
| Cell line/ mice model | MCF-7, HepG2 | |
| Additional information | Quercetin and quercetin-3-O-glucuronide are equally effective in inhibiting ROS-associated inflammation and ameliorating insulin resistant endothelial dysfunction by beneficial regulation of IRS-1 function. | |
| PubChem ID | 5274585 | |
| Additional PMIDs | 23504962 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:693386-1 | |
| Safety | NA |