| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1659 | |
| Phytochemical name or plant extracts | Qingdu granule (QDG) | |
| PMID | 1504534 | |
| Literature evidence | The average life span of H22, S180, EAC and breast carcinoma-bearing mice treated with TG ip x 2 days were 100% more than those of the control mice (P less than 0.01) TG was able to inhibit tumor growth of S37-bearing mice at the dose of 150 mg/kg per day, ig x 3, its inhibitory rate was 42% (P less than 0.01). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Traditional Chinese herbal prescription | |
| Source of phytochemicals or plant Extracts | QDG is composed of eleven herbs, such as Bupleuri Radix | |
| Geographical availability | China | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | VEGF, VEGFR2, NFATc3 | |
| Gene or Protein evidence | In breast cancer xenograft model, QDG treatment significantly suppressed tumor growth, inhibited VEGF release, and decreased microvessel density. QDG reduced protein expressions of VEGF, VEGFR2 and NFATc3. | |
| Target pathways | NFAT signaling pathway. | |
| IC50 | NA | |
| Potency | The results suggested that QDG showed anti-angiogenic effects of breast cancer both in vitro and in vivo. | |
| Cell line/ mice model | Breast cancer xenograft model | |
| Additional information | In breast cancer xenograft model, QDG treatment significantly suppressed tumor growth, inhibited VEGF release, and decreased microvessel density. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |