| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-63 | |
| Phytochemical name or plant extracts | Pyrenacantha staudtii extract | |
| PMID | 25199565 | |
| Literature evidence | CONCLUSION: PS, JCP1 and JCP2 were found to be very active against MCF-7 cells by inducing anoikis and therefore possessing vast potential as medicinal drugs especially in estrogen receptor positive breast cancer treatment. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Pyrenacantha staudtii | |
| Geographical availability | Angola, Cameroon, Congo, Gabon, Nigeria, Uganda, Zaïre | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | β1-integrin, FAK | |
| Gene or Protein evidence | In parallel cell detachment was accompanied by decreased β1- integrin expression and phosphorylation of the focal adhesion kinase at Tyr397. | |
| Target pathways | NA | |
| IC50 | 37.36 μg/ml against MCF-7 | |
| Potency | PS, JCP1 and JCP2 were found to be very active against MCF-7 cells by inducing anoikis and therefore possessing vast potential as medicinal drugs especially in estrogen receptor positive breast cancer treatment. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Jatropha curcas (JCP1), Pyrenacantha staudtii (PS) and Jatropha gossypifolia (JCP2) were found to be very active against MCF-7 cells by inducing anoikis. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:434556-1 | |
| Safety | NA |