| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1562 | |
| Phytochemical name or plant extracts | Putranjivain A | |
| PMID | 16171837 | |
| Literature evidence | Putranjivain A, isolated from the whole plant of Euphorbia jolkini Bioss (Euphorbiaceae), was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. | |
| IUPAC name | (3',4',10,11,12,15,16,17,31,32,35,36,41-tridecahydroxy-2,7,20,28-tetraoxospiro[3,6,21,24,27,34,37,40-octaoxadecacyclo[27.13.2.01,38.04,23.05,26.08,13.014,19.033,44.035,41.036,43]tetratetraconta-8,10,12,14,16,18,29,31,33(44)-nonaene-39,2'-oxolane]-25-yl) 3,4,5-trihydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Euphorbia jolkini | |
| Geographical availability | China South-Central, Japan, Korea, Nansei-shoto, Taiwan | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21, WAF1 | |
| Gene or Protein evidence | Our study reports here for the first time that the induction of p21/WAF1 and the activity of Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of putranjivain A in MCF-7 cells. | |
| Target pathways | NA | |
| IC50 | 5 µM against MCF-7 | |
| Potency | Putranjivain A inhibited the proliferation of MCF-7 by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Putranjivain A possesses antiviral activity, inhibiting viral attachment and penetration, and also interfering with the late stage of viral replication. | |
| PubChem ID | 74029796 | |
| Additional PMIDs | 14998984 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:346965-1 | |
| Safety | NA |