| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1357 | |
| Phytochemical name or plant extracts | Purple-fleshed sweet potato (PFSP) Tainung 73 | |
| PMID | 26509161 | |
| Literature evidence | Further studies also revealed that SP extracts could induce apoptosis in MCF-7 and SNU-1 cancer cells through extrinsic and intrinsic pathway. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Ipomoea batatas | |
| Geographical availability | Belize, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico Gulf, Mexico Northeast, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Venezuela | |
| Plant parts | Root tuber | |
| Other cancers | Breast cancer, Stomach cancer, Colon cancer | |
| Target gene or protein | NF-κβ, TNF-α, Caspase 3, IL-6 | |
| Gene or Protein evidence | Anthocyanin-rich extracts of PFSP TNG 73 could suppress the production of nitric oxide (NO) and some proinflammatory cytokines, such as NF-κβ, TNF-α, and IL-6, in LPS-induced macrophage cell. The results in this study demonstrated that apoptosis in SNU-1 cancer cells was only induced through the activation of caspase-3 | |
| Target pathways | Anthocyanins in SP extracts showed the ability to induce apoptosis on cancer cell line MCF-7 through both the activation of FAS receptor (extrinsic pathway) and the release of cytochrome C (mitochondrial pathway). | |
| IC50 | At 24h, 48h, 72h: Steamed, Peeled - 5.9 mg/mL, 4.3 mg/mL, 4.1 mg/mL against MCF-7 respectively Steamed, No-peeled - 4.9 mg/mL, 4.3 mg/mL, 3.4 mg/mL against MCF-7 respectively | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, SNU-1, WiDr | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1101088-2 | |
| Safety | Nevertheless, these extracts showed no cytotoxicity effect on macrophage cells. |