| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1498 | |
| Phytochemical name or plant extracts | Punicic acid | |
| PMID | 20043077 | |
| Literature evidence | Here we investigated the potential ability of punicic acid to affect growth of both an estrogen insensitive breast cancer cell line (MDA-MB-231) and an estrogen sensitive cell line developed from the MDA-MB-231 cells (MDA-ERalpha7). | |
| IUPAC name | (9Z,11E,13Z)-octadeca-9,11,13-trienoic acid | |
| Phytochemicals’ class or type of plant extracts | Omega-5 long chain polyunsaturated fatty acid | |
| Source of phytochemicals or plant Extracts | Punica granatum | |
| Geographical availability | Afghanistan, Iran, Iraq, North Caucasus, Pakistan, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Colon cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | These results suggest that punicic acid has breast cancer inhibitor properties that are dependent on lipid peroxidation and the PKC pathway. | |
| IC50 | NA | |
| Potency | Proliferation was inhibited 92 and 96% for MDA-MB-231 and MDA-ERalpha7 cells, respectively compared to untreated cells by 40 microM punicic acid. | |
| Cell line/ mice model | MDA-MB-231, MDA-ERalpha7, HepG2, Huh7, HT29 , HCT116, DU145 | |
| Additional information | Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation. Our results demonstrated that punicic acid and its congeners induce a significant decrease of cell viability for two breast cell lines with a related increase of the cell cycle G0/G1 phase respect to untreated cells. | |
| PubChem ID | 5281126 | |
| Additional PMIDs | 20043077 20136514 25149014 24962397 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:554129-1 | |
| Safety | NA |