| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-567 | |
| Phytochemical name or plant extracts | Punica granatum extract | |
| PMID | 22941571 | |
| Literature evidence | Several studies have demonstrated that polyphenolics from pomegranate (Punica granatum L.) are potent inhibitors of cancer cell proliferation and induce apoptosis, cell cycle arrest, and also decrease inflammation in vitro and vivo. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polyphenolic extract | |
| Source of phytochemicals or plant Extracts | Punica granatum | |
| Geographical availability | Afghanistan, Iran, Iraq, North Caucasus, Pakistan, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Sp1, Sp3, Sp4, miR-27a, ZBTB10, SHIP-1, miRNA-155, AKT | |
| Gene or Protein evidence | Pg extract significantly decreased Sp1, Sp3, and Sp4 as well as miR-27a in BT474 and MDA-MB-231 cells and increased expression of the transcriptional repressor ZBTB10. Pg extract also induced SHIP-1 expression and this was accompanied by downregulation of miRNA-155 and inhibition of PI3K-dependent phosphorylation of AKT. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Pomegranate extract (PE) inhibits the proliferation of breast cancer cells and stimulates apoptosis in MCF-7 breast cancer cells. | |
| Cell line/ mice model | BT-474, MDA-MB-231, MCF-7 | |
| Additional information | Pg extract also induced SHIP-1 expression and this was accompanied by downregulation of miRNA-155 and inhibition of PI3K-dependent phosphorylation of AKT. Similar results were observed in tumors from nude mice bearing BT474 cells as xenografts and treated with Pg extract. The effects of antagomirs and knockdown of SHIP-1 by RNA interference confirmed that the anti-inflammatory and cytotoxic effects of Pg extract were partly due to the disruption of both miR-27a-ZBTB10 and miR-155-SHIP-1. | |
| PubChem ID | NA | |
| Additional PMIDs | 20811693 21839626 23359482 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:554129-1 | |
| Safety | Pg extract (2.5-50 μg/ml) inhibited growth of BT-474 and MDA-MB-231 cells but not the non-cancer MCF-10F and MCF-12F cells. |