| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2188 | |
| Phytochemical name or plant extracts | Pumpkin | |
| PMID | 26976217 | |
| Literature evidence | Transactivational activity was evaluated for human androgen receptor, estrogen receptor and progesterone receptor with in vitro yeast assays. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Cucurbita maxima | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Bolivia | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Given the receptor status of some cell lines, a steroid-hormone receptor independent growth inhibiting effect can be assumed. The cell growth inhibition for fast growing cells together with the cell growth inhibition of prostate-, breast- and colon cancer cells corroborates the ethnomedical use of pumpkin seeds for a treatment of benign prostate hyperplasia. | |
| Cell line/ mice model | NA | |
| Additional information | Moreover, due to the lack of androgenic activity, pumpkin seed applications can be regarded as safe for the prostate. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30006538-2 | |
| Safety | NA |