| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1671 | |
| Phytochemical name or plant extracts | Pulveraven A | |
| PMID | 34172938 | |
| Literature evidence | As part of a continuing project to discover the bioactive natural products from wild mushrooms, we analyzed the methanol (MeOH) extract of P. ravenelii to identify metabolites with the anticancer activity. | |
| IUPAC name | methyl (2R,3R)-3-[(5Z)-5-benzylidene-4-hydroxy-2-oxofuran-3-yl]-2,3-diphenylpropanoate | |
| Phytochemicals’ class or type of plant extracts | Phenolic compound | |
| Source of phytochemicals or plant Extracts | Pulveroboletus ravenelii | |
| Geographical availability | East Asia | |
| Plant parts | Fruiting body | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 8, Caspase 7, Bax, Bcl-2 | |
| Gene or Protein evidence | Annexin V Alexa Fluor 488 binding assay and western blot results revealed that pulveraven A induced apoptotic cell death via the extrinsic apoptosis pathway, as indicated by the activation of initiator caspase-8 and executioner caspase-7. Furthermore, it was accompanied by an increase in the Bax/Bcl-2 ratio. | |
| Target pathways | Extrinsic apoptotic signaling pathway | |
| IC50 | 71.74 ± 3.61 μM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | These results suggest that pulveraven A induces apoptosis in breast cancer cells via the extrinsic apoptotic signaling pathway. | |
| PubChem ID | 54695883 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |