| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-161 | |
| Phytochemical name or plant extracts | Pulicaria undulata essential oil | |
| PMID | 22474974 | |
| Literature evidence | Bioautographic assays were used to evaluate the acetylcholinesterase inhibitory effect as well as antifungal activity of the oil against Cladosporium cucumerinum. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Essential oil | |
| Source of phytochemicals or plant Extracts | Pulicaria undulata | |
| Geographical availability | Afghanistan, Algeria, Benin, Burkina, Cameroon, Cape Verde, Chad, Djibouti, Egypt, Eritrea, Ethiopia, Ghana, Gulf States, India, Iran, Iraq, Kuwait, Libya, Mali, Mauritania, Morocco, Niger, Nigeria, Oman, Pakistan, Palestine, Saudi Arabia, Senegal, Sinai, Somalia, Sudan, Togo, Tunisia, Yemen | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | VEGFR-2 | |
| Gene or Protein evidence | The P. undulata extract and isolates showed significant reduction in tumor weight, decreased both serum vascular endothelial growth factor B (VEGF-B) levels and vascular endothelial growth factor receptor 2 (VEGFR-2) expression significantly compared to the control EAC group, suggesting an antiangiogenic activity through the inhibition of VEGF signaling. | |
| Target pathways | NA | |
| IC50 | 64.6 +/- 13.7 µg/mL against MCF-7 | |
| Potency | In this regard, we propose these compounds, isolated from P. undulata extract, as an attractive approach to combat breast cancer via the potential inhibition of tumor angiogenesis. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 34440504 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:240619-1 | |
| Safety | NA |