| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1788 | |
| Phytochemical name or plant extracts | Puerarin | |
| PMID | 22878391 | |
| Literature evidence | Since the bone absorption marker, serum tartarate-resistant acid phosphatase (TRAP) activity of puerarin-fed mice decreased but the bone formation marker, osteocalcin level, did not alter, the puerarin diet was proved to specifically depress the bone absorption, but not the overall bone metabolism. | |
| IUPAC name | 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Pueraria lobata | |
| Geographical availability | Assam, Bangladesh, Cambodia, Caroline Is., China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, India, Inner Mongolia, Japan, Jawa, Korea, Laos, Malaya, Maluku, Manchuria, Myanmar, Nansei-shoto, Nepal, New Guinea, Northern Territory, Ogasawara-shoto, Philippines, Primorye, Solomon Is., Taiwan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-κB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 5281807 | |
| Additional PMIDs | 20077420 12670155 29801513 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:967441-1 | |
| Safety | NA |