| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-696 | |
| Phytochemical name or plant extracts | Pterostilbene | |
| PMID | 31004704 | |
| Literature evidence | In addition, TMS activated the AHR more potently (EC50 in a reporter gene assay 2.0 μM) and induced AHR-mediated induction of cytochrome P450 1A1 (CYP1A1) activity (EC50 value of 0.7 μM) more than resveratrol and the other analogues tested. | |
| IUPAC name | 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol | |
| Phytochemicals’ class or type of plant extracts | Stilbenoid | |
| Source of phytochemicals or plant Extracts | Vitis rupestris | |
| Geographical availability | Arkansas, District of Columbia, Hungary, Indiana, Kentucky, Maryland, Missouri, Oklahoma, Pennsylvania, Tennessee, Texas, Virginia, West Virginia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | Beclin-1, LC3 II, hTERT, cMyc, Cyclin D1, Rac1, WAVE-2, Arp2/3 | |
| Gene or Protein evidence | Pterostilbene also caused a simultaneous increase in the expression autophagic marker proteins Beclin 1 and LC3 II (microtubule-associated protein 1 light chain 3) by approximately 6-folds, which leads to an alternative pathway of autophagy.Pterostilbene down-regulates hTERT at physiological concentrations in breast cancer cells: Potentially through the inhibition of cMyc. PT treatment regulated the protein expression of Cyclin D1 in TNBC and ER þ breast cancer cells, and also in the xenograft mouse model. In addition, pterostilbene significantly impaired the activity of Rac1 and the expression of WASP-family verprolin-homologous protein-2 (WAVE-2) and actin-related protein 2/3 (Arp2/3). | |
| Target pathways | NF-κB-mediated uPA expression and Rac1/WAVE/Arp2/3 pathway | |
| IC50 | 45.7 μM against MDA-MB-231 63.1 μM against T-47D | |
| Potency | PT could point to a promising use against the development and the progression of breast cancer as a natural therapeutic agent. | |
| Cell line/ mice model | MCF-7,MDA-MB-231 , T-47D, NCI H-460 | |
| Additional information | Pterostilbene also led to phosphatidylserine externalization, internucleosomal DNA fragmentation, caspase activation and disruption of mitochondrial membrane potential. | |
| PubChem ID | 5281727 | |
| Additional PMIDs | 24433502 22273805 24304568 29125889 32900227 24440300 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:69028-1 | |
| Safety | NA |