| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-514 | |
| Phytochemical name or plant extracts | Psoralen | |
| PMID | 26902225 | |
| Literature evidence | We measured cell viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cytotoxicity and multidrug resistance (MDR) reversal activity of psoralen. | |
| IUPAC name | furo[3,2-g]chromen-7-one | |
| Phytochemicals’ class or type of plant extracts | Furocoumarin | |
| Source of phytochemicals or plant Extracts | Psoralea corylifolia | |
| Geographical availability | Assam, Bangladesh, China South-Central, Djibouti, India, Iraq, Jawa, Laos, Malaya, Myanmar, Oman, Pakistan, Somalia, Sri Lanka, Vietnam, West Himalaya, Yemen | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Rh123, P-gp, Fra-1, Axin2, β-catenin | |
| Gene or Protein evidence | The cell cycle distribution and apoptosis, accumulation and efflux of rhodamine123 (Rh123), and P-glycoprotein (P-gp) expression levels of MCF-7/ADR cells treated with psoralen were all detected by flow cytometry (FCM). Our results demonstrate that psoralen significantly inhibited cell proliferation by inducing G0/G1 phase arrest in MCF-7 cells and G2/M phase arrest in MDA-MB-231 cells. The expression of Fra-1 was reduced and Axin2 was promoted both in MCF-7 and MDA-MB-231 cells after psoralen treatment. The cytoplasmic accumulation and nuclear translocation of β-catenin were significantly reduced by psoralen. Psoralen increased the levels of phospho-(Y142) β-catenin, while decreased the expression of total β-catenin and its downstream target Fra-1 in vitro and vivo. | |
| Target pathways | Wnt/β-catenin pathway | |
| IC50 | NA | |
| Potency | The results showed that psoralen inhibited the proliferation of MCF-7/ADR cells as shown by G0/G1 phase arrest rather than encouraging apoptosis. It was also observed that psoralen reversed MDR through inhibiting ATPase activity rather than reducing P-gp expression. | |
| Cell line/ mice model | MCF-7/ADR, MCF-7, MDA-MB-231, BALB/c nude mice | |
| Additional information | Our results further showed that psoralen inhibited the migration abilities of MCF-7/ADR cells by repressing EMT possibly through inhibiting the activation of NF-κB. | |
| PubChem ID | 6199 | |
| Additional PMIDs | 31673107 26902225 24060909 30228287 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:516049-1 | |
| Safety | Psoralen was demonstrated to inhibit the proliferation of MCF-7/ADR cells in a dose-dependent manner but no such significant effect on MCF-10A cells |