| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1937 | |
| Phytochemical name or plant extracts | Pseuderanthemum palatiferum (Nees) extract | |
| PMID | 30226114 | |
| Literature evidence | The mitochondrial transmembrane potential was disrupted in fresh leaf ethanolic extract-treated MDA-MB-231 cells and the percentage of cells with reduced mitochondrial transmembrane potential increased according to concentrations. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Pseuderanthemum palatiferum | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Laos, Malaya, Myanmar, Nepal, Sri Lanka, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Fresh leaf ethanolic extract induced human breast cancer MDA-MB-231 programmed cell death via endoplasmic reticulum and oxidative stress by activating both extrinsic and intrinsic signaling pathways. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Dichlorofluorescein level was significantly lower at high fresh leaf ethanolic extract concentrations. Total phenolic contents were found in all Pseuderanthemum palatiferum (Nees) Radlk extracts, whereas Ca2+ level in the cytosol increased, indicating Ca2+ overload and endoplasmic reticulum stress involvement with the activation of caspase-3, -8, and -9. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60454971-2 | |
| Safety | NA |