| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-815 | |
| Phytochemical name or plant extracts | Protocatechuic acid (PCA) | |
| PMID | 31627372 | |
| Literature evidence | The bark was extracted with methanol, followed by column chromatography and thus isolating kaempferol, stigmasterol, protocatechuic acid-methyl ester (PCA-ME) and protocatechuic acid (PCA). 2,2-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) and 2, 2'-diphenyl-1-picrylhydrazyl radical (DPPH) radical scavenging assays were utilized for assessment of antioxidant activity, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) dye reduction assay was used to determine cytotoxic activity against C-6 glioma rat brain, MCF-7 breast cancer, and HCT-15 colon cancer cell lines. | |
| IUPAC name | 3,4-dihydroxybenzoic acid | |
| Phytochemicals’ class or type of plant extracts | Phenolic | |
| Source of phytochemicals or plant Extracts | Bauhinia variegata | |
| Geographical availability | Assam, Bangladesh, China South-Central, East Himalaya, India, Laos, Myanmar, Nepal, Pakistan, Panamá, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Glioma, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | PCA have shown considerable cytotoxic potential against MCF-7 cell line (GI50 49.14 ± 0.23 µg/mL) | |
| Cell line/ mice model | MCF-7, C-6, HCT-15 | |
| Additional information | Protocatechuic acid is a metabolite found in or produced by Saccharomyces cerevisiae. | |
| PubChem ID | 72 | |
| Additional PMIDs | 27096779 32847047 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:481756-1 | |
| Safety | NA |