| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1204 | |
| Phytochemical name or plant extracts | Prodelphinidin B-2 3,3'-di-O-gallate | |
| PMID | 15525446 | |
| Literature evidence | Prodelphinidin B-2 3,3'-di-O-gallate (PB233'OG) is a proanthocyanidin gallate that has been reported to exhibit antioxidant and antiviral activity. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Proanthocyanidin gallate | |
| Source of phytochemicals or plant Extracts | Myrica rubra | |
| Geographical availability | China South-Central, China Southeast, Hainan, Japan, Korea, Nansei-shoto, Philippines, Taiwan | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, p21/WAF1 | |
| Gene or Protein evidence | The results showed that PB233'OG induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. | |
| Target pathways | Fas/Fas ligand apoptotic system is the main pathway | |
| IC50 | 5.2 µM against MCF-7 for 48h | |
| Potency | Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the anti-proliferative activity of PB233'OG in MCF-7 cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The results showed that PB233'OG induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of PB233'OG-mediated apoptosis of MCF-7 cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:585602-1 | |
| Safety | NA |