| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-367 | |
| Phytochemical name or plant extracts | Pristimerin | |
| PMID | 16093444 | |
| Literature evidence | Treatment of tumor cells with pristimerin resulted in a rapid release of cytochrome c from mitochondria, which preceded caspase activation and the decrease of mitochondrial membrane potential. | |
| IUPAC name | methyl (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Reissantia buchananii | |
| Geographical availability | Botswana, Malawi, Mozambique, Tanzania, Zambia, Zimbabwe | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Pancreatic cancer, Leukemia | |
| Target gene or protein | FASN | |
| Gene or Protein evidence | (FASN) expression and FASN activity were downregulated by pristimerin. | |
| Target pathways | Pristimerin overcomes adriamycin resistance in breast cancer cells through suppressing Akt signaling, Pristimerin induces apoptosis and autophagy via activation of ROS/ASK1/JNK pathway in human breast cancer in vitro and in vivo. | |
| IC50 | pristimerin inhibited the cell viability of A549, MCF-7, MDA-MB-231, HepG2, and Hep3B cells, with IC50 values ranging from 0.42 to 0.61 μmol/L after a 72-hour treatment. | |
| Potency | pristimerin showed the most potent activity against nine tumor cancer cell lines, including vincristine-resistant oropharyngeal cancer KB cells and taxol-resistant ovarian cancer PTX10 cells, a potent and broad-spectrum antitumor agent, with activity against a wide range of different human cancers. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Pristimerin did not significantly alter the protein level of Bcl-2 family members (Bcl-2, Bcl-X(L), and Bax), nor did it induce Bax translocation. Moreover, Bcl-2 overexpression fails to prevent pristimerin-induced apoptosis. | |
| PubChem ID | 159516 | |
| Additional PMIDs | 23370361 17541980 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:431143-1 | |
| Safety | NA |