| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-906 | |
| Phytochemical name or plant extracts | Prim-O-glucosylcimifugin | |
| PMID | 31462297 | |
| Literature evidence | RESULTS: Traditional Chinese medicine saposhnikovia root extract Prim-O-glucosylcimifugin (POG) could bind well to the target proteins and inhibit the proliferation, metabolism and immunosuppressive ability of PMN-MDSCs by inhibiting arginine metabolism and the tricarboxylic acid cycle (TCA cycle). | |
| IUPAC name | (2S)-2-(2-hydroxypropan-2-yl)-4-methoxy-7-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-2,3-dihydrofuro[3,2-g]chromen-5-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Saposhnikovia divaricata | |
| Geographical availability | Amur, Buryatiya, China North-Central, Chita, Inner Mongolia, Kazakhstan, Korea, Manchuria, Mongolia, Primorye | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Arg-1, iNOS | |
| Gene or Protein evidence | The results showed that POG decreased the expression of Arg-1 and iNOS in PMN-MDSC. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | POG was successfully screened from the traditional Chinese Medicine library as a PMN-MDSC inhibitor. POG exhibited a good synergistic antitumour effect with PD-1 inhibitor. This study provided a potential option for enhancing the efficacy of PD-1 inhibitors in clinical applications. | |
| Cell line/ mice model | B16-F10, (4 T1) mouse tumour models | |
| Additional information | Traditional Chinese medicine saposhnikovia root extract Prim-O-glucosylcimifugin (POG) could bind well to the target proteins and inhibit the proliferation, metabolism and immunosuppressive ability of PMN-MDSCs by inhibiting arginine metabolism and the tricarboxylic acid cycle (TCA cycle). POG could also increase CD8 T-lymphocyte infiltration in the tumours and enhance the antitumour effect of PD-1 inhibitor in B16-F10 and 4 T1 mouse tumour models. | |
| PubChem ID | 14034912 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:847902-1 | |
| Safety | NA |