| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1607 | |
| Phytochemical name or plant extracts | Porphyridium cruentum sulfated polysaccharides | |
| PMID | 33805009 | |
| Literature evidence | To determine their ability to induce cytokine production Tumor Necrosis Factor alpha (TNF-α) and interleukina-6 (IL-6), the immunomodulatory activity of the PcSPs has been evaluated. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Sulfated polysaccharides | |
| Source of phytochemicals or plant Extracts | Porphyridium cruentum | |
| Geographical availability | Saline water | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colorectal cancer, Leukemia, Lung cancer | |
| Target gene or protein | IL-6, TNF-α | |
| Gene or Protein evidence | The results obtained indicate that the polysaccharides from P. cruentum are potent inducers of IL-6 cytokines and, most importantly, of TNF-α. | |
| Target pathways | NA | |
| IC50 | 1089.63 µg/mL against MCF-7 | |
| Potency | The cytotoxic capacity of PcSPs was measured by the MTT colorimetric assay in colorectal carcinoma (HTC-116), human leukemia (U-937 and HL-60), breast cancer (MCF-7), lung cancer (NCI-H460) and human gingival fibroblasts (HGF-1) cell lines. The IC50 value of 2311.20 µg mL-1, 1676.74 µg mL-1, 1089.63 µg mL-1, 5498.14 µg mL-1 and 2861.49 µg mL-1 respectively in the tumor lines | |
| Cell line/ mice model | HTC-116, U-937, HL-60, MCF-7, NCI-H460, HGF-1/ male Balb/C mice | |
| Additional information | Furthermore, the in vivo study revealed an improvement of local inflammatory response against stress in the peritoneum. These findings suggest that the PcSPs from P. cruentum might have potential as a valuable ingredient in nutraceutical products. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |