| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-868 | |
| Phytochemical name or plant extracts | Pomolic acid | |
| PMID | 27912873 | |
| Literature evidence | BACKGROUND: Pomolic acid (PA), an active triterpenoid from Euscaphis japonica, inhibits the proliferation of a variety of cancer cells, but the molecular mechanisms of the anti-angiogenic potential of PA have not been fully elucidated in breast cancer cells. | |
| IUPAC name | (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Euscaphis japonica | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Hainan, Japan, Korea, Nansei-shoto, Taiwan, Vietnam | |
| Plant parts | Leaves and Root | |
| Other cancers | Breast cancer, Prostate cancer, Lung cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | PA suppresses EGF-induced HIF1α protein translation by inhibiting the p38-MAPK and mTOR kinase signaling pathways | |
| IC50 | NA | |
| Potency | PA has a potent inhibitory effect on the human platelet aggregation selectively activated by ADP and epinephrine. | |
| Cell line/ mice model | Human breast cancer cells, MCF-7 and MDA-MB-231, and human umbilical vascular endothelial cells (HUVEC). | |
| Additional information | Furthermore, PA inhibited EGF-induced angiogenesis in vitro and downregulated HIF1α/VEGF expression in HUVEC. | |
| PubChem ID | 382831 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:821926-1 | |
| Safety | NA |