| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1135 | |
| Phytochemical name or plant extracts | Pomiferin | |
| PMID | 22087557 | |
| Literature evidence | In vitro, pomiferin, but not osajin, demonstrated selective antiproliferative activity against the tumorigenic breast epithelial cell line MCF-7 (IC(50) = 5.2 μM) with limited toxicity toward nontumorigenic breast epithelial cells (MCF-10A). | |
| IUPAC name | 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Maclura pomifera | |
| Geographical availability | Arkansas, Oklahoma, Texas | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | With a stringent cutoff of p < 0.01, a total of 94 genes were significantly differentially expressed between MCF-7 and MCF-10A cells, 80 up-regulated and 14 down-regulated when cells were exposed to 5 μM pomiferin for 24 h. | |
| Target pathways | NA | |
| IC50 | 5.2 ± 0.9 μM against MCF-7 | |
| Potency | Moreover, they showed a more potent antiproliferative effect against ER+ (MCF-7) than ER- one (MDA-MB-231) cell lines. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 4871 | |
| Additional PMIDs | 34139914 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:148738-2 | |
| Safety | NA |