| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2166 | |
| Phytochemical name or plant extracts | Pomegranate seed oil (PSO) | |
| PMID | 24962397 | |
| Literature evidence | Taken together, the data herein suggest a potential synergistic cytotoxic, anti-inflammatory and anti-oxidant role of the polar compounds from PSO. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous methanol extract | |
| Source of phytochemicals or plant Extracts | Punica granatum | |
| Geographical availability | Afghanistan, Iran, Iraq, North Caucasus, Pakistan, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan | |
| Plant parts | Seed | |
| Other cancers | Breast cancer, Liver cancer, Colon cancer, Prostate cancer | |
| Target gene or protein | VEGF, IL-2, IL-6, IL-12, IL-17, IP-10, MIP-1α, MIP-1β, MCP-1, TNF-α | |
| Gene or Protein evidence | Moreover, the evaluation of a great panel of cytokines expressed by MCF-7 and MDA-MB-231 cells showed that the levels of VEGF and nine pro-inflammatory cytokines (IL-2, IL-6, IL-12, IL-17, IP-10, MIP-1α, MIP-1β, MCP-1 and TNF-α) decreased in a dose dependent way with increasing amounts of the hydrophilic extracts of PSO, supporting the evidence of an anti-inflammatory effect. | |
| Target pathways | NA | |
| IC50 | 0.60 μL against MDA-MB-231 0.50 μL against MCF-7 | |
| Potency | Taken together, the data herein suggest a potential synergistic cytotoxic, anti-inflammatory and anti-oxidant role of the polar compounds from PSO. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HT29, HepG2, HuH7, HCT116, DU145 | |
| Additional information | After 24 h of challenge, HT29, HepG2, HuH7, HCT116 and DU145 cells retained a relatively constant viability at increasing dose of hydrophilic extract from PSO. The decrease in cell viability (evaluated as means and standard errors) became significant for two breast cell lines, MDA-MB-231 and MCF-7, which reached IC50 at doses of 0.60 μL and 0.50 μL extracts, respectively. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:554129-1 | |
| Safety | NA |