| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1171 | |
| Phytochemical name or plant extracts | Pomegranate extract | |
| PMID | 23359482 | |
| Literature evidence | While PE is a potent antioxidant, the present studies were conducted to examine the mechanisms of action of PE beyond antioxidation by studying cellular and molecular mechanisms underlying breast tumorigenesis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Punica granatum | |
| Geographical availability | Afghanistan, Iran, Iraq, North Caucasus, Pakistan, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan | |
| Plant parts | Peels | |
| Other cancers | Breast cancer, Uterus cancer, Cervical cancer, Ovarian cancer | |
| Target gene or protein | MRE11, RAD50, NBS1, RAD51, BRCA1, BRCA2, BRCC3, miR-183, miR-24 | |
| Gene or Protein evidence | Both microarray and quantitative RT-PCR indicated that PE downregulated important genes involved in DNA double strand break (DSB) repair by homologous recombination (HR), such as MRE11, RAD50, NBS1, RAD51, BRCA1, BRCA2, and BRCC3. Downregulation of HR genes correlated with increased levels of their predicted microRNAs (miRNAs), miR-183 (predicted target RAD50) and miR-24 (predicted target BRCA1), suggesting that PE may regulate miRNAs involved in DNA repair processes. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Pomegranate extract (PE) inhibits the proliferation of breast cancer cells and stimulates apoptosis in MCF-7 breast cancer cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HEC-1A, SiHa, HeLa, SKOV3, MCF-10A | |
| Additional information | DNA microarray analysis revealed that PE downregulated genes associated with mitosis, chromosome organization, RNA processing, DNA replication and DNA repair, and upregulated genes involved in regulation of apoptosis and cell proliferation. | |
| PubChem ID | NA | |
| Additional PMIDs | 20043077 20811693 21839626 23359482 33671442 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:554129-1 | |
| Safety | NA |