| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-232 | |
| Phytochemical name or plant extracts | Pomaces from Muscadinia rotundifolia | |
| PMID | 29249924 | |
| Literature evidence | F3 also demonstrated the greatest ability to induce apoptosis via caspase activation and cell cycle arrest by downregulating cyclin A and upregulating p21. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Pomaces | |
| Source of phytochemicals or plant Extracts | Muscadinia rotundifolia | |
| Geographical availability | Alabama, Arkansas, Bahamas, Delaware, Florida, Georgia, Kentucky, Louisiana, Maryland, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southwest, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, Virginia, West Virginia | |
| Plant parts | Seeds and skin | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin A, p21 | |
| Gene or Protein evidence | F3 also demonstrated the greatest ability to induce apoptosis via caspase activation and cell cycle arrest by downregulating cyclin A and upregulating p21. | |
| Target pathways | NA | |
| IC50 | 12.88 ± 2.69 µg DW/mL | |
| Potency | F3 was thus the most effective bioactive fraction among those prepared from muscadine grape 'Noble' pomace | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Two different cell inhibitory concentrations, IC80 (80% maximal inhibitory concentration) and IC50 (50% maximal inhibitory concentration), of each fraction were calculated based on the inhibition curve. The IC80 and IC50 values of F2 were 20.85 ± 2.37 and 9.75 ± 0.52 µg DW/mL, respectively. These values were significantly lower than those of F1 in which the IC80 was 29.64 ± 1.50 µg DW/mL and the IC50 was 17.82 ± 2.42 µg DW/mL, but they were similar to those for F3, which was 25.00 ± 1.73 and 12.88 ± 2.69 µg DW/mL for IC80 and IC50, respectively | |
| PubChem ID | NA | |
| Additional PMIDs | 28329437 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:308496-2 | |
| Safety | NA |