| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1889 | |
| Phytochemical name or plant extracts | Polysaccharide SpaTA | |
| PMID | 28267497 | |
| Literature evidence | Taken together, these results indicated that SpaTA can induce the apoptosis of breast cancer cells through regulating ERα. Therefore, SpaTA may be considered as an effective agent against human breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polysccharide | |
| Source of phytochemicals or plant Extracts | Sparganii Rhizoma | |
| Geographical availability | China | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERα | |
| Gene or Protein evidence | Taken together, these results indicated that SpaTA can induce the apoptosis of breast cancer cells through regulating ERα. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Moreover, knock-down ERα in ZR-75-1 cells and overexpress ERα in MDA-MB-231 cells also provided evidences that SpaTA activated the apoptosis-related caspase -3, -8, -9 and PARP in an ERα-dependent manner. | |
| Cell line/ mice model | ZR-75-1, MDA-MB-231 | |
| Additional information | SpaTA had a backbone consisting of 2-O-grailsine-β-xylose (4→6)-α-glucose (1→4) -β-mannose osamine. There is an aluminium element combined with nitrogen on both grailsine and mannose osamine in repeating unit of SpaTA. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |